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Bavarian Nordic’s RSV Vax Achieves Positive Results

Analysis suggests that the vaccine has the desired effect of boosting memory responses against RSV

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By: Kristin Brooks

Managing Editor, Contract Pharma

Bavarian Nordic achieved positive data from its Phase II study investigating the safety and immune effects of its universal RSV vaccine, MVA-BN RSV in an older adult population. 

In a planned follow-up analysis, there was an approximately 1.5-fold increase in IgA antibodies over baseline levels, with peak increases seen in the weeks immediately following vaccination. The boosting effect was more pronounced in individuals with a lower baseline mucosal IgA at the time of vaccination. This observation suggests that the vaccine has the desired effect of boosting memory responses against RSV in patients with a poor underlying immunity. 

MVA-BN RSV has been specifically designed to mimic a natural RSV infection, and can boost the body’s memory response against RSV. The vaccine has been shown to elicit T-cells and humoral antibodies against each of the 5 targets encoded in the vaccine, as well as the whole virus. Previously reported data demonstrated that the vaccine induced sustained protection levels for up to 6 months, the duration of an RSV season, against all 5 encoded targets when compared to a placebo.

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